Eicosanoid receptors: Targets for the treatment of disrupted intestinal epithelial homeostasis

@article{Moreno2017EicosanoidRT,
  title={Eicosanoid receptors: Targets for the treatment of disrupted intestinal epithelial homeostasis},
  author={J. J. Moreno},
  journal={European Journal of Pharmacology},
  year={2017},
  volume={796},
  pages={7–19}
}
  • J. J. Moreno
  • Published 2017
  • Chemistry, Medicine
  • European Journal of Pharmacology
ABSTRACT The importance of cyclooxygenase and lipoxygenase pathways and the consequent eicosanoid synthesis in the physiology and pathophysiology of the intestinal epithelium is currently being established. Each eicosanoid (prostanoid, leukotriene, hydroxyeicosatetraenoic acid) preferentially recognizes one or more receptors coupled to one or more signal‐transduction processes. This overview focuses on the role of eicosanoid receptors in the maintenance of intestinal epithelium physiology… Expand
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2
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References

SHOWING 1-10 OF 184 REFERENCES
Role of eicosanoids on intestinal epithelial homeostasis.
TLDR
This overview focuses on the physiological and physiopathological roles of eicosanoids in cell growth/cell differentiation/apoptosis and in the paracellular permeability of the intestinal epithelium. Expand
Role of 12-lipoxygenase derived eicosanoids on epithelial barrier function in intestinal Caco-2 cells
Eicosanoids are lipid mediators synthesized by the arachidonic acid (AA) cascade from membrane polyunsaturated fatty acids (PUFA) trough three distinct pathways: cyclooxygenase, lipooxygenase (LOX)Expand
Effect of eicosapentaenoic acid-derived prostaglandin E3 on intestinal epithelial barrier function.
TLDR
The results indicate that PGE3 increased paracellular permeability to the same extent as PGE2, through the interaction with EP1 and EP4 receptors and with intracellular Ca(2+) and cAMP as the downstream targets. Expand
Regulation of inflammation in cancer by eicosanoids.
TLDR
Eicosanoids may represent a missing link between inflammation and cancer and thus could serve as therapeutic target(s) for inhibiting tumor growth, and is reviewed in the context of tumorigenesis. Expand
The Role of Leukotriene Receptor Signaling in Inflammation and Cancer
TLDR
This review summarizes the role of LTs and PGs in chronic inflammation and delineates how continuous CysLT1 receptor activation and signaling can increase cell survival and proliferation as important early steps toward oncogenicity. Expand
Enzymes and receptors in the leukotriene cascade
TLDR
This chapter reviews the biochemistry, molecular biology and cell biology of the key enzymes and cognate receptors in the leukotriene cascade. Expand
Prostaglandins and epithelial response to injury
  • W. Stenson
  • Medicine
  • Current opinion in gastroenterology
  • 2007
TLDR
Endogenous PGE2 has pro-proliferative and antiapoptotic effects on epithelial cells in gastrointestinal injury and binds to EP receptors; EP2 appears to be especially important in mediating the protective effects of P GE2 on epitocyte cells. Expand
5-Hydroxyeicosatetraenoic acid and leukotriene D4 increase intestinal epithelial paracellular permeability.
TLDR
It is proposed that 5-lipoxygenase pathway metabolites participate in the disruption of epithelial barrier function that is characteristic of inflammatory bowel disease. Expand
Characterization of the cysteinyl leukotriene 2 receptor in novel expression sites of the gastrointestinal tract.
TLDR
It is suggested that a lack of neuronal expression of CysLT₂R in the murine colonic myenteric plexus attenuates colitis disease progression via a reduction in inflammation-associated tissue edema and increases neuronal sensitivity to nociceptive stimuli. Expand
Prostanoid receptors in intestinal epithelium: selective expression, function, and change with inflammation.
TLDR
Dual immunostaining and in situ hybridization with digoxygenin-labelled RNA probes largely confirmed the epithelial localization of EP 4 and protection of epithelium from the effects of T cell cytokines during inflammation. Expand
...
1
2
3
4
5
...