Eicosanoid receptors: Targets for the treatment of disrupted intestinal epithelial homeostasis

@article{Moreno2017EicosanoidRT,
  title={Eicosanoid receptors: Targets for the treatment of disrupted intestinal epithelial homeostasis},
  author={Juan J. Moreno},
  journal={European Journal of Pharmacology},
  year={2017},
  volume={796},
  pages={7–19}
}
  • J. J. Moreno
  • Published 5 February 2017
  • Biology, Medicine
  • European Journal of Pharmacology

Figures and Tables from this paper

Role of arachidonic acid-derived eicosanoids in intestinal innate immunity

Eicosanoids generation in intestine and their role in intestinal innate immunity, focusing on intestinal epithelial barrier, innate immune cell in lamina propria (LP) and their crosstalk are reviewed.

THE ROLE OF 20-HETE IN LUNG CANCERS

Evaluating the role of 20-HETE in lung cancers in both pathophysiological and physiological states finds that it represents liver CYP-dependent AA metabolism (50% – 75%) along with its association to liver cirrhotic ascites.

Prostanoids and leukotrienes in the pathophysiology of atopic dermatitis and psoriasis.

The current findings on the roles of prostanoids and LTs in AD and psoriasis as revealed by studies in mice are summarized, and the potential of these lipid mediators as therapeutic targets in humans is discussed.

Clinical Implications of 20-Hydroxyeicosatetraenoic Acid in the Kidney, Liver, Lung and Brain: An Emerging Therapeutic Target

The role of 20-HETE in the kidney, liver, lung, and brain during physiological and pathophysiological states, as well as in tumor formation, metabolic syndrome and diabetes, is discussed.

Dual Behavior of Long-Chain Fatty Acids and Their Cyclooxygenase/Lipoxygenase Metabolites on Human Intestinal Caco-2 Cell Growth

The results demonstrated that oleic acid is a potent mitogenic factor to Caco-2 cells, at least in part, through 10-hydroxy-8-octadecenoic synthesized by lipoxigenase pathway, whereas polyunsaturated FAs such as eicosapentaenoic (EPA) acid has a dual behavior effect depending on its concentration.

Oxygenated lipid signaling in tumor-associated macrophages—focus on colon cancer

The purpose of this review is to give an overview of what is currently known regarding PUFA-derived mediator signaling in tumor-associated macrophages in CRC.

Inhibitors of Eicosanoid Biosynthesis Reveal that Multiple Lipid Signaling Pathways Influence Malaria Parasite Survival in Anopheles gambiae

Eicosanoids are bioactive signaling lipids derived from the oxidation of fatty acids that act as important regulators of immune homeostasis and inflammation. As a result, effective anti-inflammatory

EP2 Receptor Blockade Attenuates COX-2 Upregulation During Intestinal Inflammation.

The results indicate that the EP2 receptor plays a critical role in the positive feedback regulation of intestinal COX-2 by its end-product PGE2 during inflammation and may be a novel therapeutic target in the treatment of NEC.

References

SHOWING 1-10 OF 172 REFERENCES

Role of eicosanoids on intestinal epithelial homeostasis.

Role of 12-lipoxygenase derived eicosanoids on epithelial barrier function in intestinal Caco-2 cells

It is demonstrated that 12-(R) and 12-(S)-HETE, eicosanoids derived from n-6 PUFA, but not 12-HEPE are able to disrupt epithelial barrier function, which could be an explanation of the beneficial role of fish oil in IBD.

Regulation of inflammation in cancer by eicosanoids.

The Role of Leukotriene Receptor Signaling in Inflammation and Cancer

This review summarizes the role of LTs and PGs in chronic inflammation and delineates how continuous CysLT1 receptor activation and signaling can increase cell survival and proliferation as important early steps toward oncogenicity.

Enzymes and receptors in the leukotriene cascade

This chapter reviews the biochemistry, molecular biology and cell biology of the key enzymes and cognate receptors in the leukotriene cascade.

Prostaglandins and epithelial response to injury

  • W. Stenson
  • Biology, Medicine
    Current opinion in gastroenterology
  • 2007
Endogenous PGE2 has pro-proliferative and antiapoptotic effects on epithelial cells in gastrointestinal injury and binds to EP receptors; EP2 appears to be especially important in mediating the protective effects of P GE2 on epitocyte cells.

5-Hydroxyeicosatetraenoic acid and leukotriene D4 increase intestinal epithelial paracellular permeability.

Prostanoid receptors in intestinal epithelium: selective expression, function, and change with inflammation.

Eicosanoid signalling pathways in the development and progression of colorectal cancer: novel approaches for prevention/intervention

The effects of the eicosanoids on tumor cell proliferation, their roles in cell death induction, effects on angiogenesis, migration, invasion and their regulation of the immune response are discussed.
...