Eicosanoid-dependent and -independent formation of individual [14C]stearoyl-labelled lysophospholipids in collagen-stimulated human platelets.

@article{Thomas1991EicosanoiddependentA,
  title={Eicosanoid-dependent and -independent formation of individual [14C]stearoyl-labelled lysophospholipids in collagen-stimulated human platelets.},
  author={Lisa M. Thomas and Bruce John Holub},
  journal={Biochimica et biophysica acta},
  year={1991},
  volume={1081 1},
  pages={92-8}
}
Low level collagen activation of platelets is mediated via the release of arachidonic acid (AA) from membrane phospholipids and the formation of thromboxane A2 (TxA2). To assess the specific phospholipids undergoing deacylation via phospholipase A2 thereby providing source(s) of releasable AA, we have measured the individual lysophospholipid formations in platelets prelabelled with [14C]stearic acid and incubated with a low level (2 micrograms/ml) or a high level (10 micrograms/ml) of collagen… CONTINUE READING