Eicosanoid activation of protein kinase C epsilon: involvement in growth cone repellent signaling.

@article{Mikule2003EicosanoidAO,
  title={Eicosanoid activation of protein kinase C epsilon: involvement in growth cone repellent signaling.},
  author={Keith Mikule and Somkiat Sunpaweravong and Jesse C. Gatlin and Karl H. Pfenninger},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 23},
  pages={
          21168-77
        }
}
Exposure of growing neurons to thrombin or semaphorin 3A stimulates a receptor-mediated signaling cascade that results in collapse of their growth cones. This collapse response necessitates eicosanoid production, as we have shown earlier. The present report investigates whether and which protein kinase C (PKC) isoforms may be activated by such eicosanoids. To examine these questions, we isolated growth cones from fetal rat brain and tested whether thrombin or the eicosanoid, 12(S… CONTINUE READING

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