Ehlers-Danlos syndrome with severe early-onset periodontal disease (EDS-VIII) is a distinct, heterogeneous disorder with one predisposition gene at chromosome 12p13.

@article{Rahman2003EhlersDanlosSW,
  title={Ehlers-Danlos syndrome with severe early-onset periodontal disease (EDS-VIII) is a distinct, heterogeneous disorder with one predisposition gene at chromosome 12p13.},
  author={Nazneen Rahman and Melanie L Dunstan and M Dawn Teare and Sandra Hanks and J. B. Douglas and Kim Coleman and William E. Bottomly and Mary E. Campbell and Britta E Berglund and Magnus Nordenskj{\"o}ld and Bengt Forssell and Nigel Burrows and Peter Lunt and Ian R. Young and Stephanie D. Williams and Graham R. Bignell and P. Andrew Futreal and F. M. Pope},
  journal={American journal of human genetics},
  year={2003},
  volume={73 1},
  pages={
          198-204
        }
}
Ehlers-Danlos VIII (EDS-VIII) is an autosomal dominant disorder characterized by severe early-onset periodontal disease in conjunction with the features of Ehlers-Danlos syndrome (EDS). We performed a genomewide linkage search in a large Swedish pedigree with EDS-VIII and established linkage to a 7-cM interval on chromosome 12p13, generating a maximum multipoint LOD score of 5.17. Analysis of four further pedigrees with EDS-VIII revealed two consistent with linkage to 12p13 and two in which… CONTINUE READING
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