Ehlers‐Danlos syndrome – a historical review

@article{Parapia2008EhlersDanlosS,
  title={Ehlers‐Danlos syndrome – a historical review},
  author={Liakat Ali Parapia and Carolyn Jackson},
  journal={British Journal of Haematology},
  year={2008},
  volume={141}
}
Ehlers‐Danlos syndrome is an inherited heterogeneous group of connective tissue disorders, characterized by abnormal collagen synthesis, affecting skin, ligaments, joints, blood vessels and other organs. It is one of the oldest known causes of bruising and bleeding and was first described by Hipprocrates in 400 BC. Edvard Ehlers, in 1901, recognized the condition as a distinct entity. In 1908, Henri‐Alexandre Danlos suggested that skin extensibility and fragility were the cardinal features of… 

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TLDR
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TLDR
This work proposes a revision of the classification of the Ehlers-Danlos syndromes based primarily on the cause of each type based on major and minor diagnostic criteria defined for each type and complemented whenever possible with laboratory findings.

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TLDR
The terminology needs revision, so that the importance of one of the symptoms, hyperlaxity or hyperflexibility of the joints, is considered.