Egr2 targets identify a population of dysfunctional T cells in the tumor microenvironment with immune modulatory properties

@inproceedings{Williams2013Egr2TI,
  title={Egr2 targets identify a population of dysfunctional T cells in the tumor microenvironment with immune modulatory properties},
  author={Jason B. Williams and Yan Zheng and Thomas F Gajewski},
  booktitle={Journal for ImmunoTherapy of Cancer},
  year={2013}
}
Although the presence of tumor-infiltrating lymphocytes (TILs) indicates an endogenous anti-tumor response, immune regulatory pathways can subvert the effector phase and enable tumor escape. Negative regulatory pathways include expression of inhibitory receptors and corresponding ligands, metabolic dysregulation, recruitment of suppressive cell populations, and T cell-intrinsic anergy. Recently, we have shown that the transcription factor Egr2 is critical in controlling the anergic state using… CONTINUE READING