Egr1 Transcription Factor: Multiple Roles in Prostate Tumor Cell Growth and Survival

  title={Egr1 Transcription Factor: Multiple Roles in Prostate Tumor Cell Growth and Survival},
  author={E. D. Adamson and Dan Mercola},
  journal={Tumor Biology},
  pages={93 - 102}
The transcription factor, Egr1, so-called because it is encoded by the immediate early growth response gene, Egr1, is rapidly induced by growth factors to transduce the proliferative signal. The induction of Egr1 by external stimuli is generally transient but appears to be sustained in some prostate tumor cell lines and tumors, suggesting that Egr1 stimulates tumor cell growth. In contradiction, in breast, lung and brain tumors, Egr1 expression is often absent or reduced and when re-expressed… 

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