Egr-1 mediates leptin-induced PPARγ reduction and proliferation of pulmonary artery smooth muscle cells

@inproceedings{Xie2018Egr1ML,
  title={Egr-1 mediates leptin-induced PPARγ reduction and proliferation of pulmonary artery smooth muscle cells},
  author={Xinming Xie and Shaojun Li and Yanting Zhu and Lu Liu and Rui Ke and Jian Wang and Xin Yan and Lan Yang and Li Gao and Wei-Jin Zang and Man-xiang Li},
  booktitle={Molecular biology of the cell},
  year={2018}
}
Loss of peroxisome proliferator-activated receptor γ (PPARγ) has been found to contribute to pulmonary artery smooth muscle cell (PASMC) proliferation and pulmonary arterial remodeling therefore the development of pulmonary hypertension (PH). Yet, the molecular mechanisms underlying PPARγ reduction in PASMC remain poorly understood. Here, we demonstrated that leptin dose- and time-dependently inducued PPARγ down-regulation and proliferation of primary cultured rat PASMC, this was accompanied… CONTINUE READING
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