Egr-1 is a Major Vascular Pathogenic Transcription Factor in Atherosclerosis and Restenosis

@article{Blaschke2004Egr1IA,
  title={Egr-1 is a Major Vascular Pathogenic Transcription Factor in Atherosclerosis and Restenosis},
  author={Florian Blaschke and Dennis Bruemmer and Ronald E. Law},
  journal={Reviews in Endocrine and Metabolic Disorders},
  year={2004},
  volume={5},
  pages={249-254}
}
The zinc finger transcription factor Egr-1 (early growth response factor-1), also known as nerve growth factorinduced-A (NGFI-A), zif268, Krox-24 and TIS8 was first identified by Sukhatme and colleagues [1]. It is the prototype of a family of zinc-finger transcription factors, that includes Egr-2, Egr-3 and Egr-4. Egr-1 is rapidly and transiently expressed in many different cell types in response to a variety of extracellular stimuli, including growth factors, cytokines and injurious stimuli [2… 
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Transcription factor and kinase-mediated signaling in atherosclerosis and vascular injury

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Curcumin is a potent inhibitor of key components of the IGF-1-induced mitogenic and proliferative signaling system in VSMC, and it is suggested that curcumin-induced attenuation of these signaling components may constitute a potential mechanism for its vasculoprotective effects.

Attenuation of endothelin-1-induced PKB and ERK1/2 signaling, as well as Egr-1 expression, by curcumin in A-10 vascular smooth muscle cells.

Curcumin is a potent inhibitor of ET-1-induced mitogenic and proliferative signaling events in VSMC and the ability of curcumin to attenuate these events may contribute as a potential mechanism for its cardiovascular protective response.

Role of receptor and non-receptor protein tyrosine kinases in vasoactive peptide-induced signaling

This work investigated whether IGF-1R transactivation plays a similar role in ET-1 and Ang II-induced PKB phosphorylation and hypertrophic responses in VSMC.

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