Egr-1 is a Major Vascular Pathogenic Transcription Factor in Atherosclerosis and Restenosis
@article{Blaschke2004Egr1IA, title={Egr-1 is a Major Vascular Pathogenic Transcription Factor in Atherosclerosis and Restenosis}, author={Florian Blaschke and Dennis Bruemmer and Ronald E. Law}, journal={Reviews in Endocrine and Metabolic Disorders}, year={2004}, volume={5}, pages={249-254} }
The zinc finger transcription factor Egr-1 (early growth response factor-1), also known as nerve growth factorinduced-A (NGFI-A), zif268, Krox-24 and TIS8 was first identified by Sukhatme and colleagues [1]. It is the prototype of a family of zinc-finger transcription factors, that includes Egr-2, Egr-3 and Egr-4. Egr-1 is rapidly and transiently expressed in many different cell types in response to a variety of extracellular stimuli, including growth factors, cytokines and injurious stimuli [2…
70 Citations
Regulation of the Early Growth Response Protein-1 in vascular smooth muscle cells
- Biology
- 2017
The role of Ca2+ signaling in Ang-IIinduced Egr-1 expression in VSMC is examined and the contribution of STIM-1 or Orai-1 is investigated as well as the associated signalling pathways.
Early Growth Response protein 1 (Egr-1) expression by Insulin-like growth factor 1 (IGF-1) involves MAPKs and PKB pathways
- Biology
- 2015
It is shown that IGF-1 stimulates the expression of Egr-1 through ERK1/2/JNK and PI3K/PKB and proposed that ROS generation plays an important role in this response.
Anticoagulant effect of wogonin against tissue factor expression.
- Biology, MedicineEuropean journal of pharmacology
- 2019
Lysophosphatidic Acid Induces Early Growth Response Gene 1 Expression in Vascular Smooth Muscle Cells: CRE and SRE Mediate the Transcription
- BiologyArteriosclerosis, thrombosis, and vascular biology
- 2006
It is found that LPA markedly induces Egr-1 mRNA and protein in aortic smooth muscle cells (SMCs) and a novel role for CREB in mediating LPA-induced gene expression is established, implying that elevated LPA levels may exacerbate atheromatous lesions.
Early Growth Response Protein 1 Promotes Restenosis by Upregulating Intercellular Adhesion Molecule-1 in Vein Graft
- BiologyOxidative medicine and cellular longevity
- 2013
Egr-1 may promote ECs proliferation and result in vein graft restenosis by upregulating the expression of ICAM-1, and could be a target for the prevention of restenotic after CABG surgery.
Transcription factor and kinase-mediated signaling in atherosclerosis and vascular injury
- BiologyCurrent atherosclerosis reports
- 2006
The focus of this review is to summarize the current understanding of a finite group of transcription factors and kinases involved in vascular injury and atherosclerosis, including nuclear factor-κB, early growth response factor-I (Egr-I), activator protein-I, hypoxia inducible factor- Iα (HIF-Iα), homeobox, and T cell factor/lymphoid enhancer factor (Tcf-Lef).
Insulin-like growth-factor-1-induced PKB signaling and Egr-1 expression is inhibited by curcumin in A-10 vascular smooth muscle cells.
- BiologyCanadian journal of physiology and pharmacology
- 2013
Curcumin is a potent inhibitor of key components of the IGF-1-induced mitogenic and proliferative signaling system in VSMC, and it is suggested that curcumin-induced attenuation of these signaling components may constitute a potential mechanism for its vasculoprotective effects.
Attenuation of endothelin-1-induced PKB and ERK1/2 signaling, as well as Egr-1 expression, by curcumin in A-10 vascular smooth muscle cells.
- BiologyCanadian journal of physiology and pharmacology
- 2012
Curcumin is a potent inhibitor of ET-1-induced mitogenic and proliferative signaling events in VSMC and the ability of curcumin to attenuate these events may contribute as a potential mechanism for its cardiovascular protective response.
Role of receptor and non-receptor protein tyrosine kinases in vasoactive peptide-induced signaling
- Biology, Chemistry
- 2012
This work investigated whether IGF-1R transactivation plays a similar role in ET-1 and Ang II-induced PKB phosphorylation and hypertrophic responses in VSMC.
Berberine suppresses MEK/ERK-dependent Egr-1 signaling pathway and inhibits vascular smooth muscle cell regrowth after in vitro mechanical injury.
- Biology, MedicineBiochemical pharmacology
- 2006
References
SHOWING 1-10 OF 77 REFERENCES
Vascular smooth muscle cells express the transcriptional corepressor NAB2 in response to injury.
- BiologyThe American journal of pathology
- 1999
Egr-1-Induced Endothelial Gene Expression: A Common Theme in Vascular Injury
- BiologyScience
- 1996
These findings implicate Egr-1 in the up-regulated expression of PDGF-B and other potent mediators in mechanically injured arterial endothelial cells.
Early growth response protein 1 (Egr-1): prototype of a zinc-finger family of transcription factors.
- BiologyProgress in nucleic acid research and molecular biology
- 1995
Egr-1 Activates Basic Fibroblast Growth Factor Transcription
- BiologyThe Journal of Biological Chemistry
- 1996
It is concluded that the astrocyte mitogen, ET-3, stimulates egr-1 transcription through a MAP kinase (Erk) related mechanism, and that EGr-1 transactivates bFGF through a specific noncanonical, Egr- 1 site on the promoter.
Matrix-dependent gene expression of egr-1 and PDGF A regulate angiotensin II-induced proliferation in human vascular smooth muscle cells.
- Biology, MedicineHypertension
- 1999
In human vascular smooth muscle cells in culture, Ang II-induced proliferation is mediated via the angiotensin type 1 receptor, dependent on ECM proteins, and regulated by differential gene expression of Egr-1 and PDGF-1.
High-level expression of Egr-1 and Egr-1-inducible genes in mouse and human atherosclerosis.
- BiologyThe Journal of clinical investigation
- 2000
Induction of atherosclerosis in LDL receptor-null mice by feeding them a high-fat diet resulted in a progressive increase in Egr-1 expression in the aorta, indicating that induction of EGr-1 by atherogenic factors may be a key step in coordinating the cellular events that result in vascular lesions.
Angiotensin II type 1 receptor blockade inhibits the expression of immediate-early genes and fibronectin in rat injured artery.
- Biology, MedicineCirculation
- 1995
Inhibition of intimal thickening by AT1 receptor blockade may be mediated at least in part by suppression of multiple genes related to cell growth and migration in the very early phase after vascular injury.
Differential Regulation of Early Growth Response Gene-1 Expression by Insulin and Glucose in Vascular Endothelial Cells
- Biology, MedicineArteriosclerosis, thrombosis, and vascular biology
- 2003
Differential regulation of Egr-1 expression by insulin and glucose in vascular cells may be one of the initial key events that plays a crucial role in the development of diabetic vascular complications.
Interplay of Sp1 and Egr-1 in the Proximal Platelet-derived Growth Factor A-Chain Promoter in Cultured Vascular Endothelial Cells (*)
- BiologyThe Journal of Biological Chemistry
- 1995
Findings demonstrate that PMA-induced Egr-1 displaces Sp1 from the G+C-rich element and activates expression driven by the PDGF-A proximal promoter in endothelial cells, which may be an important regulatory circuit in the control of inducible gene expression in vascular endothelial Cells.