Egr-1 Mediates Transcriptional Repression of COL 2 A 1 Promoter Activity by Interleukin-1 *

@inproceedings{Tan2003Egr1MT,
  title={Egr-1 Mediates Transcriptional Repression of COL 2 A 1 Promoter Activity by Interleukin-1 *},
  author={Lujian Tan and Haibing Peng and Makoto Osaki and Bob K. Choy and Philip E. Auron and Linda J. Sandell and Mary B Goldring},
  year={2003}
}
Following induction and activation of the early growth response (Egr)-1 transcription factor in human chondrocytes, interleukin-1 (IL-1 ) suppresses the expression of the type II collagen gene (COL2A1), associated with induction of Egr-1 binding activity in nuclear extracts. The COL2A1 proximal promoter contains overlapping binding sites for Egr-1 and Sp1 family members at 119/ 112 bp and 81/ 74 bp. Mutations that block binding of Sp1 and Sp3 to either site markedly reduce constitutive… CONTINUE READING
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Egr-1 Represses COL2A1 Promoter Activity 17700 by gest on O cber 4, 2017 hp://w w w .jb.org/ D

  • K. Okazaki, J. Li, H. Yu, N. Fukui, L. J. Sandell
  • J. Biol. Chem
  • 2002

Goldring, manuscript in preparation. Interleukin-1-induced Egr-1 Represses COL2A1 Promoter Activity 17699 by gest on O cber 4, 2017 hp://w w w .jb.org/ D

  • V. Lefebvre, P. Li, B. de Crombrugghe
  • EMBO J. 17,
  • 1998
2 Excerpts

Arthritis and Allied Conditions: A Textbook of Rheumatology (Koopman

  • A. R. Poole
  • W. J.,
  • 1997
1 Excerpt

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