Efrapeptin J, a New Down-regulator of the Molecular Chaperone GRP78 from a Marine Tolypocladium sp.

  title={Efrapeptin J, a New Down-regulator of the Molecular Chaperone GRP78 from a Marine Tolypocladium sp.},
  author={Y. Hayakawa and Y. Hattori and T. Kawasaki and K. Kanoh and K. Adachi and Y. Shizuri and K. Shin-ya},
  journal={The Journal of Antibiotics},
  • Y. Hayakawa, Y. Hattori, +4 authors K. Shin-ya
  • Published 2008
  • Medicine, Biology
  • The Journal of Antibiotics
  • A new down-regulator of the molecular chaperone GRP78, efrapeptin J, was isolated from a marine fungus, Tolypocladium sp. AMB18. The molecular formula of efrapeptin J was established as C81H139N18O16+ by high-resolution FAB-MS. The structure was elucidated to be a linear pentadecapeptide containing a hexahydropyrrolo[1,2-a]pyrimidinium moiety by NMR and MS analyses. Efrapeptins F, G and J dose-dependently inhibited 2-deoxyglucose-induced luciferase expression in HT1080 human fibrosarcoma cells… CONTINUE READING
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