Efflux transporter engineering markedly improves amorphadiene production in Escherichia coli.

@article{Zhang2016EffluxTE,
  title={Efflux transporter engineering markedly improves amorphadiene production in Escherichia coli.},
  author={Congqiang Zhang and Xixian Chen and Gregory Stephanopoulos and Heng-Phon Too},
  journal={Biotechnology and bioengineering},
  year={2016},
  volume={113 8},
  pages={1755-63}
}
Metabolic engineering aims at altering cellular metabolism to produce valuable products at high yields and titers. Achieving high titers and productivity can be challenging if final products are largely accumulated intracellularly. A potential solution to this problem is to facilitate the export of these substances from cells by membrane transporters. Amorphadiene, the precursor of antimalarial drug artemisinin, is known to be secreted from Escherichia coli overexpressing the biosynthetic… CONTINUE READING
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