Efflux transport of serum amyloid P component at the blood-brain barrier.

@article{Veszelka2013EffluxTO,
  title={Efflux transport of serum amyloid P component at the blood-brain barrier.},
  author={Szilvia Veszelka and Judit Laszy and Tam{\'a}s P{\'a}zm{\'a}ny and L{\'a}szl{\'o} N{\'e}meth and Izabella Ob{\'a}l and L{\'a}szl{\'o} F{\'a}bi{\'a}n and G{\'a}bor Sz{\'a}bo and Csongor S. {\'A}brah{\'a}m and M{\'a}ria A Deli and Zolt{\'a}n Urb{\'a}nyi},
  journal={European journal of microbiology & immunology},
  year={2013},
  volume={3 4},
  pages={281-9}
}
Serum amyloid P component (SAP), a member of the innate immune system, does not penetrate the brain in physiological conditions; however, SAP is a stabilizing component of the amyloid plaques in neurodegenerative diseases. We investigated the cerebrovascular transport of human SAP in animal experiments and in culture blood-brain barrier (BBB) models. After… CONTINUE READING