Efflux of taurocholic acid across the blood-brain barrier: interaction with cyclic peptides.

@article{Kitazawa1998EffluxOT,
  title={Efflux of taurocholic acid across the blood-brain barrier: interaction with cyclic peptides.},
  author={Takatoshi Kitazawa and Tetsuya Terasaki and Hiroshi Suzuki and A Kakee and Yuichi Sugiyama},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1998},
  volume={286 2},
  pages={890-5}
}
The mechanism for the efflux of taurocholic acid (TC) across the blood-brain barrier (BBB) was studied by examining the elimination of [3H]TC after microinjection into the cerebral cortex. The efflux of [3H]TC from the brain was saturable with a Vmax of 15.0 pmol/min/g brain and a Km value of 0.396 nmol/0.2 microl injectate. Efflux was inhibited by cholic acid (CA), a cationic cyclic octapeptide (octreotide; a somatostatin analogue) and an anionic cyclic pentapeptide (BQ-123; an endothelin… CONTINUE READING
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References

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Peptide Derug Delivery to the Brain

  • WM Pardridge
  • 1991
Highly Influential
4 Excerpts

Blood-brain barrier function of P-glycoprotein

  • A Tsuji, I Tamai
  • Adv Drug Deliv Rev 25:287–298
  • 1997
Highly Influential
3 Excerpts

Molecular mechanisms of hepatic bile salt transport from sinusoidal blood into bile

  • PJ Meier
  • Am J Physiol 269:G801–G812
  • 1995
Highly Influential
4 Excerpts

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