Efflux of adenine nucleotides from rat liver mitochondria.

A rapid and selective efflux of 75 to 80% of the intramitochondrial adenine nucleotides (AdN) has been obtained by incubation with 5 mm Mgff and 10 mM inorganic phosphate in the presence of 1 mM ethylenediaminetetraacetate, with little or no decrease in the P:O ratio, active respiratory state, or size of the pyridine nucleotide pool. The initial rate of AdN… (More)