Efflux-mediated multidrug resistance in Bacillus subtilis: similarities and dissimilarities with the mammalian system.

@article{Neyfakh1991EffluxmediatedMR,
  title={Efflux-mediated multidrug resistance in Bacillus subtilis: similarities and dissimilarities with the mammalian system.},
  author={Alexander A. Neyfakh and Vladimir Bidnenko and Lan Bo Chen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 11},
  pages={4781-5}
}
Bacillus subtilis cells selected for their resistance to rhodamine 6G demonstrated a multidrug-resistance (MDR) phenotype resembling that of mammalian MDR cells. Like MDR in mammalian cells, MDR in bacteria was mediated by the efflux of the drugs from the cells. The bacterial multidrug efflux system transported similar drugs and was sensitive to similar inhibitors as the mammalian multidrug transporter, P-glycoprotein. The gene coding for the bacterial multidrug transporter, like the P… CONTINUE READING

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