Efflux Transporters Regulate Arsenite-Induced Genotoxicity in Double Negative and Double Positive T Cells.

Abstract

Arsenite (As+3) exposure is known to cause immunotoxicity in human and animal models. Our previous studies demonstrated that As+3 at 50-500 nM concentrations induced both genotoxicity and nongenotoxicity in mouse thymus cells. Developing T cells at CD4-CD8- double negative (DN) stage, the first stage after early T cells are transported from bone marrow to… (More)
DOI: 10.1093/toxsci/kfx075

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Cite this paper

@article{Xu2017EffluxTR, title={Efflux Transporters Regulate Arsenite-Induced Genotoxicity in Double Negative and Double Positive T Cells.}, author={Huan Xu and Sebasti{\'a}n F. Medina and Fredine T. Lauer and Christelle C. Douillet and Ke Liu and Laurie G. Hudson and Miroslav Stỳblo and Lauren M. Aleksunes and Scott W. Burchiel}, journal={Toxicological sciences : an official journal of the Society of Toxicology}, year={2017}, volume={158 1}, pages={127-139} }