Effluent from drug manufacturing affects cytochrome P450 1 regulation and function in fish.

@article{Beijer2013EffluentFD,
  title={Effluent from drug manufacturing affects cytochrome P450 1 regulation and function in fish.},
  author={Kristina Beijer and Kai Gao and Maria E. J{\"o}nsson and D. G. Joakim Larsson and Bj{\"o}rn Brunstr{\"o}m and I. Brandt},
  journal={Chemosphere},
  year={2013},
  volume={90 3},
  pages={1149-57}
}
We have previously reported very high concentrations of pharmaceuticals in the effluent from a treatment plant receiving wastewater from about 90 bulk drug manufacturers near Hyderabad, India. The main objective of the present study was to examine how high dilutions of this effluent affect mRNA expression of cytochrome P450 (CYP) 1 family genes and ethoxyresorufin O-deethylase (EROD) activity in exposed wildlife, using the three-spined stickleback (Gasterosteus aculeatus) as a model. In gill… CONTINUE READING
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