Efficient virus extinction by combinations of a mutagen and antiviral inhibitors.

@article{Pariente2001EfficientVE,
  title={Efficient virus extinction by combinations of a mutagen and antiviral inhibitors.},
  author={Nonia Pariente and Saleta Sierra and Pedro Ricardo Lowenstein and Esteban Domingo},
  journal={Journal of virology},
  year={2001},
  volume={75 20},
  pages={9723-30}
}
The effect of combinations of the mutagenic base analog 5-fluorouracil (FU) and the antiviral inhibitors guanidine hydrochloride (G) and heparin (H) on the infectivity of foot-and-mouth disease virus (FMDV) in cell culture has been investigated. Related FMDV clones differing up to 10(6)-fold in relative fitness in BHK-21 cells have been compared. Systematic extinction of intermediate fitness virus was attained with a combination of FU and G but not with the mutagen or the inhibitor alone… CONTINUE READING