Efficient utilization of complex N-linked glycans is a selective advantage for Bacteroides fragilis in extraintestinal infections.

@article{Cao2014EfficientUO,
  title={Efficient utilization of complex N-linked glycans is a selective advantage for Bacteroides fragilis in extraintestinal infections.},
  author={Yanlu Cao and Edson R Rocha and C Jeffrey Smith},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 35},
  pages={
          12901-6
        }
}
Bacteroides fragilis is the most common anaerobe isolated from clinical infections, and in this report we demonstrate a characteristic of the species that is critical to their success as an opportunistic pathogen. Among the Bacteroides spp. in the gut, B. fragilis has the unique ability of efficiently harvesting complex N-linked glycans from the glycoproteins common to serum and serous fluid. This activity is mediated by an outer membrane protein complex designated as Don. Using the abundant… CONTINUE READING

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