Efficient two-step testing of gene-gene interactions in genome-wide association studies.

@article{Lewinger2013EfficientTT,
  title={Efficient two-step testing of gene-gene interactions in genome-wide association studies.},
  author={Juan Pablo Lewinger and John L Morrison and Duncan C Thomas and Cassandra Elizabeth Murcray and David V. Conti and Dalin Li and William James Gauderman},
  journal={Genetic epidemiology},
  year={2013},
  volume={37 5},
  pages={440-51}
}
Exhaustive testing of all possible SNP pairs in a genome-wide association study (GWAS) generally yields low power to detect gene-gene (G × G) interactions because of small effect sizes and stringent requirements for multiple-testing correction. We introduce a new two-step procedure for testing G × G interactions in case-control GWAS to detect interacting single nucleotide polymorphisms (SNPs) regardless of their marginal effects. In an initial screening step, all SNP pairs are tested for gene… CONTINUE READING
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