Efficient treatment of infertility due to sperm DNA damage by ICSI with testicular spermatozoa.

@article{Greco2005EfficientTO,
  title={Efficient treatment of infertility due to sperm DNA damage by ICSI with testicular spermatozoa.},
  author={Ermanno Greco and Filomena Scarselli and Marcello Iacobelli and Laura Rienzi and Filippo Maria Ubaldi and Susanna Ferrero and Giorgio Franco and Nazareno Anniballo and Carmen Mendoza and Jan Tesarik},
  journal={Human reproduction},
  year={2005},
  volume={20 1},
  pages={
          226-30
        }
}
BACKGROUND Sperm DNA damage (fragmentation) is a recently discovered cause of male infertility for which no efficient treatment has yet been found. Previous findings have suggested that clinically relevant sperm DNA damage may occur at the post-testicular level. This study was undertaken to assess the clinical usefulness of ICSI with testicular spermatozoa in this indication. METHODS The percentage of spermatozoa with fragmented DNA, assessed by terminal deoxyribonucleotidyl transferase… 
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Oral antioxidant treatment appears to improve ICSI outcomes in those patiens with sperm DNA damage, in whom this treatment reduces the percentage of damaged spermatozoa.
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ICSI with testicular sperm for couples with sperm DNA damage
  • A. Zini
  • Medicine, Biology
    International braz j urol : official journal of the Brazilian Society of Urology
  • 2018
TLDR
Sperm DNA damage is more common in men with poor semen parameters than in those with normal parameters and in 2008 a systematic review and meta-analysis of 2,162 IVF and ICSI treatment cycles demonstrated a potential adverse effect of sperm DNA damage on the chance of pregnancy.
Relationships between human sperm protamines, DNA damage and assisted reproduction outcomes.
Clinical relevance of sperm DNA damage in assisted reproduction.
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It is suggested that sperm DNA damage as measured by the TUNEL assay may provide an indicator for patients with poor fertilization rates and/or those unable to achieve pregnancy following ART treatment.
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