Efficient transgene regulation from a single tetracycline-controlled positive feedback regulatory system

@article{AMohammadi1998EfficientTR,
  title={Efficient transgene regulation from a single tetracycline-controlled positive feedback regulatory system},
  author={S A-Mohammadi and R B Hawkins},
  journal={Gene Therapy},
  year={1998},
  volume={5},
  pages={76-84}
}
Control of gene expression in eukaryotic cells is clearly important in many applications including modifications of the level of a therapeutic gene product. For effective gene delivery and regulation, the regulatory system must be contained on a single vector and it must exhibit high transgene expression on induction and low basal expression on repression. Here, we have investigated several self-contained vectors carrying both the tetracycline-controlled transactivator (tTA) and a potentially… CONTINUE READING

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