Efficient transduction of green fluorescent protein in spinal cord neurons using adeno-associated virus vectors containing cell type-specific promoters

@article{Peel1997EfficientTO,
  title={Efficient transduction of green fluorescent protein in spinal cord neurons using adeno-associated virus vectors containing cell type-specific promoters},
  author={A E Peel and Sergei Zolotukhin and GW Schrimsher and Nicholas Muzyczka and P Reier},
  journal={Gene Therapy},
  year={1997},
  volume={4},
  pages={16-24}
}
In this study, we have evaluated the capacity of recombinant adeno-associated virus (rAAV) vectors, containing cell type-specific promoters, to transduce neurons in vivo in the normal adult rat spinal cord. The neuron-specific enolase (NSE) promoter and the platelet-derived growth factor (PDGF) B-chain promoter were used to direct expression of a ‘humanized’ form of the gene for green fluorescent protein (GFP). Neuron-specific rAAVs were injected into the mid-cervical regions of adult rat… CONTINUE READING

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