Efficient trans-complementation of the flavivirus kunjin NS5 protein but not of the NS1 protein requires its coexpression with other components of the viral replicase.

@article{Khromykh1999EfficientTO,
  title={Efficient trans-complementation of the flavivirus kunjin NS5 protein but not of the NS1 protein requires its coexpression with other components of the viral replicase.},
  author={Alexander A Khromykh and Petra L. Sedlak and Kimberley Guyatt and Roy A Hall and Edwin G. Westaway},
  journal={Journal of virology},
  year={1999},
  volume={73 12},
  pages={
          10272-80
        }
}
Successful trans-complementation of the defective Kunjin virus (KUN) RNA FLdGDD with a deletion of the RNA polymerase motif GDD in the NS5 gene by using a BHK cell line, repBHK, that continuously produced a functionally active KUN replication complex (RC) from replicon RNA was recently reported (A. A. Khromykh, M. T. Kenney, and E. G. Westaway, J. Virol. 72:7270-7279, 1998). In order to identify whether this complementation of FLdGDD RNA was provided by the wild-type NS5 protein alone or with… CONTINUE READING

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