Efficient three-step one-pot synthesis of a novel 2,3,5-substituted pyrazine library.

@article{Delvare2011EfficientTO,
  title={Efficient three-step one-pot synthesis of a novel 2,3,5-substituted pyrazine library.},
  author={Christian Delvare and Craig S Harris and Laurent Hennequin and Patrice Koza and Christine Lambert-van der Brempt and Jacques Pelleter and Olivier Willerval},
  journal={ACS combinatorial science},
  year={2011},
  volume={13 5},
  pages={449-52}
}
The partnership between rational synthesis design and mass-triggered preparative LCMS is a powerful one, capable of furnishing very large libraries in a selective manner in a very short space of time. Herein, we communicate one example of possibly a perfect marriage between the synthetic chemistry and the subsequent purification method employed, affording a ∼1000-member library supplying 50 mg on average of final compound in less than a month.