Efficient targeting of CD13 on cancer cells by the immunotoxin scFv13–ETA′ and the bispecific scFv [13xds16]

@article{Grieger2017EfficientTO,
  title={Efficient targeting of CD13 on cancer cells by the immunotoxin scFv13–ETA′ and the bispecific scFv [13xds16]},
  author={Elena Grieger and Gerrit Gresch and Judith Niesen and Mira Woitok and Stefan Barth and Reinhard Fischer and Rolf Fendel and Christoph W. Stein},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2017},
  volume={143},
  pages={2159-2170}
}
PurposeTreatment of cancer using standard chemotherapy still offers a poor prognosis combined with severe side effects. Novel antibody-based therapies have been shown to overcome low efficiency and lack of selectivity by targeting cancer-associated antigens, such as aminopeptidase CD13.MethodsWe isolated a high-affinity CD13-specific single-chain fragment variable (scFv13) from a phage display library of V-genes from mice immunized with soluble antigen. An immunotoxin comprising the scFv13 and… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 49 REFERENCES

Bispecific Antibodies as a Development Platform for New Concepts and Treatment Strategies

  • International journal of molecular sciences
  • 2016
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Immunotoxins for targeted cancer therapy.

  • The AAPS journal
  • 1998
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Aminopeptidase N (APN/CD13) as a target molecule for scirrhous gastric cancer.

  • Clinics and research in hepatology and gastroenterology
  • 2016
VIEW 1 EXCERPT