Efficient synthesis of sugar oxazolines from unprotected N-acetyl-2-amino sugars by using chloroformamidinium reagent in water.

Abstract

Sugar oxazoline derivatives were directly synthesized from the corresponding N-acetyl-2-amino sugars in aqueous media by using a chloroformamidinium-type dehydrating reagent. The present method could successfully be applied to chito-oligosaccharides, saccharides with acid functions, and a complex-type oligosaccharide derived from a glycopeptide.

DOI: 10.1021/jo8024708
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@article{Noguchi2009EfficientSO, title={Efficient synthesis of sugar oxazolines from unprotected N-acetyl-2-amino sugars by using chloroformamidinium reagent in water.}, author={Masato Noguchi and Tomonari Tanaka and Hidetoshi Gyakushi and Atsushi Kobayashi and Shin-ichiro Shoda}, journal={The Journal of organic chemistry}, year={2009}, volume={74 5}, pages={2210-2} }