Efficient synthesis of phthaloyl derivatives of α-amino carboxamides

A rapid and one-pot synthesis of phthaloyl derivatives of α-amino carboxamides is described. In dichloromethane, α-amino carboxamides react with mono-methylphthalate in the presence of BOP and i-Pr2NEt to afford the intermediate N α-[(o-methoxycarbonyl)benzoyl]amino carboxamides which undergo cyclization in dichloromethane/water in the presence of aqueous… CONTINUE READING

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