Efficient synthesis of isofagomine and noeuromycin.

@article{Andersch2001EfficientSO,
  title={Efficient synthesis of isofagomine and noeuromycin.},
  author={J Andersch and Mikael Bols},
  journal={Chemistry},
  year={2001},
  volume={7 17},
  pages={3744-7}
}
Starting from D-arabinose the synthesis of the very strong glycosidase inhibitors isofagomine (2) and noeuromycin (3) was achieved in six and seven steps, respectively. Keystep in the reaction sequence is the application of an efficient C-4 oxidation method to benzyl alpha-D-arabino-pyranoside. Subsequent Henry reaction of the obtained aldoketose with… CONTINUE READING