Efficient synthesis of functionalized organozinc compounds by the direct insertion of zinc into organic iodides and bromides.

@article{Krasovskiy2006EfficientSO,
  title={Efficient synthesis of functionalized organozinc compounds by the direct insertion of zinc into organic iodides and bromides.},
  author={Arkady L. Krasovskiy and Vladimir Malakhov and Andrei Gavryushin and Paul Knochel},
  journal={Angewandte Chemie},
  year={2006},
  volume={45 36},
  pages={
          6040-4
        }
}
Significance: Organozinc compounds are very useful intermediates in synthesis of complex organic molecules due to their high reactivity combined with an excellent tolerance of functional groups. So far, the direct insertion of commercial zinc dust into organic halides was limited only to alkyl iodides and tertiary bromides, which diminished its synthetic value. Herein, a new method, allowing the preparation of aryland hetarylzinc iodides, alkyland several arylzinc bromides by the direct… 
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Mild Negishi cross-coupling reactions catalyzed by acenaphthoimidazolylidene palladium complexes at low catalyst loadings.
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The catalyst system displayed superiority in the construction of heterobiaryls through the coupling of heteroarylzinc reagents and heterocylic chloroarenes which were hardly accessible from the corresponding organoboron reagents by Suzuki-coupling reactions.
C60-Catalyzed Preparation of Aryl and Heteroaryl Magnesium and Zinc Reagents Using Mg/LiCl
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