Efficient synthesis of both diastereomers of β,γ-diamino acids from phenylalanine and tryptophan

Abstract

We synthesized in a few steps both diastereomers of orthogonally protected β,γ-diamino acids starting from l-phenylalanine or l-tryptophan. These final compounds are interesting building blocks for peptide synthesis and foldamer chemistry. The key step is a Blaise reaction performed under ultrasound conditions. 
DOI: 10.1007/s00726-016-2262-8

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