Efficient synthesis of Guanfu base G via highly regioselective lipase-catalyzed acylation in non-aqueous phase.

@article{Xia2012EfficientSO,
  title={Efficient synthesis of Guanfu base G via highly regioselective lipase-catalyzed acylation in non-aqueous phase.},
  author={Ye Xia and Ji-Hua Liu and Jing-han Liu and Boyang Yu},
  journal={Bioorganic & medicinal chemistry letters},
  year={2012},
  volume={22 9},
  pages={3100-3}
}
Lipase-catalyzed acylation of Guanfu alcohol-amine (GFAA) with vinyl acetate (VA) was performed in non-aqueous system for the preparation of Guanfu base G (GFG), a plant-originated alkaloid with significant antiarrhythmic activity. Among the eight lipases from different origins, Novozym 435 was found to be the best biocatalyst. The most suitable molecular… CONTINUE READING