Efficient synthesis of γ-lactones via gold-catalyzed tandem cycloisomerization/oxidation.

Abstract

A novel Au-catalyzed tandem cycloisomerization/oxidation of homopropargyl alcohols was developed. Various γ-lactones can be accessed readily by utilizing this strategy. Notably, the mechanism of this reaction is distinctively different from the related Ru-catalyzed reactions where the ruthenium vinylidene intermediate was proposed. 

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Cite this paper

@article{Shu2012EfficientSO, title={Efficient synthesis of γ-lactones via gold-catalyzed tandem cycloisomerization/oxidation.}, author={Chao Shu and Meng-Qi Liu and Yu-Zhe Sun and Long-Wu Ye}, journal={Organic letters}, year={2012}, volume={14 18}, pages={4958-61} }