Efficient synthesis of α- and δ-carbolines by sequential Pd-catalyzed site-selective C-C and twofold C-N coupling reactions.

@article{Hung2015EfficientSO,
  title={Efficient synthesis of α- and δ-carbolines by sequential Pd-catalyzed site-selective C-C and twofold C-N coupling reactions.},
  author={T. Q. Hung and Tuan Dang and J. Janke and A. Villinger and P. Langer},
  journal={Organic & biomolecular chemistry},
  year={2015},
  volume={13 5},
  pages={
          1375-86
        }
}
  • T. Q. Hung, Tuan Dang, +2 authors P. Langer
  • Published 2015
  • Chemistry, Medicine
  • Organic & biomolecular chemistry
    • Two concise and efficient approaches were developed for the synthesis of α- and δ-carboline derivatives. The success of the synthesis relies on site-selective Suzuki-Miyaura reactions of 1-chloro-2-bromopyridine or 2,3-dibromopyridine with 2-bromophenylboronic acid and subsequent cyclization with amines which proceeds by twofold Pd-catalyzed C-N coupling reactions. 
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