Efficient suppression of gene expression by targeting 5'-UTR-based RNA quadruplexes with bisquinolinium compounds.


G-quadruplexes are well-characterized, four-stranded conformations comprised of stacked arrangements of guanine nucleobase tetrads, stabilized by Hoogsteen hydrogen bonding and centrally coordinated cations. The stable formation of quadruplexes has been studied for both DNA and RNA sequences. Many such sequences were characterized in the promoter regions of… (More)
DOI: 10.1002/cbic.201100228


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