Efficient study designs for test of genetic association using sibship data and unrelated cases and controls.

@article{Li2006EfficientSD,
  title={Efficient study designs for test of genetic association using sibship data and unrelated cases and controls.},
  author={Mingyao Li and Michael Boehnke and Gonçalo R. Abecasis},
  journal={American journal of human genetics},
  year={2006},
  volume={78 5},
  pages={
          778-792
        }
}
Linkage mapping of complex diseases is often followed by association studies between phenotypes and marker genotypes through use of case-control or family-based designs. Given fixed genotyping resources, it is important to know which study designs are the most efficient. To address this problem, we extended the likelihood-based method of Li et al., which assesses whether there is linkage disequilibrium between a disease locus and a SNP, to accommodate sibships of arbitrary size and disease… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
65 Extracted Citations
30 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 65 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 30 references

Similar Papers

Loading similar papers…