Efficient stereospecific synthesis of no-carrier-added 2-[18F]-fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution.

@article{Hamacher1986EfficientSS,
  title={Efficient stereospecific synthesis of no-carrier-added 2-[18F]-fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution.},
  author={Karl Hamacher and Heinz Hubert Coenen and Gerhard St{\"o}cklin},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={1986},
  volume={27 2},
  pages={235-8}
}
An aminopolyether mediated synthesis of fluorine-18 (18F) 2-fluoro-2-deoxy-D-glucose (FDG) has been developed. The nucleophilic fluorination with accelerator-produced [18F]fluoride works at the no-carrier-added level and gives epimerically pure 2-18FDG with an uncorrected radiochemical yield of a maximum 50% in a synthesis time of approximately 50 min from EOB.