Efficient specification of interneurons from human pluripotent stem cells by dorsoventral and rostrocaudal modulation.

@article{Kim2014EfficientSO,
  title={Efficient specification of interneurons from human pluripotent stem cells by dorsoventral and rostrocaudal modulation.},
  author={Tae-Gon Kim and Ruiqin Yao and Travis E. Monnell and Jun-Hyeong Cho and Anju Vasudevan and Alice A. Koh and Kumar T Peeyush and Minho Moon and Debkanya Datta and Vadim Y Bolshakov and Kwang-Soo Kim and Sangmi Chung},
  journal={Stem cells},
  year={2014},
  volume={32 7},
  pages={1789-804}
}
GABAergic interneurons regulate cortical neural networks by providing inhibitory inputs, and their malfunction, resulting in failure to intricately regulate neural circuit balance, is implicated in brain diseases such as Schizophrenia, Autism, and Epilepsy. During early development, GABAergic interneuron progenitors arise from the ventral telencephalic area such as medial ganglionic eminence (MGE) and caudal ganglionic eminence (CGE) by the actions of secreted signaling molecules from nearby… CONTINUE READING
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