Efficient size control of amphiphilic cyclodextrin nanoparticles through a statistical mixture design methodology.

@article{Choisnard2005EfficientSC,
  title={Efficient size control of amphiphilic cyclodextrin nanoparticles through a statistical mixture design methodology.},
  author={Luc Choisnard and Annabelle G{\'e}ze and Muriel Bigan and Jean-Luc Putaux and Denis Wouessidjewe},
  journal={Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques},
  year={2005},
  volume={8 3},
  pages={
          593-601
        }
}
PURPOSE the aim of the study was to investigate size control of amphiphilic beta-cyclodextrin nanoparticles obtained by solvent displacement technique. METHODS An experimental design methodology for mixture design was undertaken using D-optimal approach with the following technique variables: water fraction X1 (40-70% v/v), acetone fraction X2 (0-60% v/v) and ethanol fraction X3 (0-60% v/v). RESULTS The resulting quadratic model obtained after logarithmic transformation of data and partial… CONTINUE READING

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