Efficient single tobamoviral vector-based bioproduction of broadly neutralizing anti-HIV-1 monoclonal antibody VRC01 in Nicotiana benthamiana plants and utility of VRC01 in combination microbicides.

@article{Hamorsky2013EfficientST,
  title={Efficient single tobamoviral vector-based bioproduction of broadly neutralizing anti-HIV-1 monoclonal antibody VRC01 in Nicotiana benthamiana plants and utility of VRC01 in combination microbicides.},
  author={Krystal Teasley Hamorsky and Tiffany W Grooms-Williams and Adam S. Husk and Lauren J. Bennett and Kenneth E. Palmer and Nobuyuki Matoba},
  journal={Antimicrobial agents and chemotherapy},
  year={2013},
  volume={57 5},
  pages={2076-86}
}
Broadly neutralizing monoclonal antibodies (bnMAbs) may offer powerful tools for HIV-1 preexposure prophylaxis, such as topical microbicides. However, this option is hampered due to expensive MAb biomanufacturing based on mammalian cell culture. To address this issue, we developed a new production system for bnMAb VRC01 in Nicotiana benthamiana plants using a tobamovirus replicon vector. Unlike conventional two-vector-based expression, this system was designed to overexpress full-length IgG1… CONTINUE READING

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