Efficient serum clearance of botulinum neurotoxin achieved using a pool of small antitoxin binding agents.

Abstract

Antitoxins for botulinum neurotoxins (BoNTs) and other toxins are needed that can be produced economically with improved safety and shelf-life properties compared to conventional therapeutics with large-animal antisera. Here we show that protection from BoNT lethality and rapid BoNT clearance through the liver can be elicited in mice by administration of a… (More)
DOI: 10.1128/IAI.01084-09

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