Efficient semiparametric estimation of haplotype-disease associations in case-cohort and nested case-control studies.

@article{Zeng2006EfficientSE,
  title={Efficient semiparametric estimation of haplotype-disease associations in case-cohort and nested case-control studies.},
  author={Donglin Zeng and Dan-Yu Lin and Christy L. Avery and Kari E. North and Molly S. Bray},
  journal={Biostatistics},
  year={2006},
  volume={7 3},
  pages={486-502}
}
Estimating the effects of haplotypes on the age of onset of a disease is an important step toward the discovery of genes that influence complex human diseases. A haplotype is a specific sequence of nucleotides on the same chromosome of an individual and can only be measured indirectly through the genotype. We consider cohort studies which collect genotype data on a subset of cohort members through case-cohort or nested case-control sampling. We formulate the effects of haplotypes and possibly… CONTINUE READING

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