Efficient self-assembly of Archaeoglobus fulgidus ferritin around metallic cores.


Interfacing biological systems with inorganic nanoparticles is of great interest, as it offers means of particle stabilization and spatial control in electronic or biomedical applications. We report on the particle-directed assembly of hyperthermophile Archaeoglobus fulgidus ferritin subunits around negatively charged colloidal gold. An annealing process allows rapid assembly of the protein in near-native stoichiometry. Transmission electron microscopy suggests that greater than 95% of nanoparticles are encapsulated while the self-assembly process ensures that almost 100% of the assembled ferritin cavities are occupied.

DOI: 10.1021/la8040743

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@article{Swift2009EfficientSO, title={Efficient self-assembly of Archaeoglobus fulgidus ferritin around metallic cores.}, author={Joe Swift and Christopher A Butts and Jasmina C Cheung-Lau and Vijay Yerubandi and Ivan J Dmochowski}, journal={Langmuir : the ACS journal of surfaces and colloids}, year={2009}, volume={25 9}, pages={5219-25} }