Efficient screening of p53 mutations by denaturing gradient gel electrophoresis in colorectal tumors.

@article{Hamelin1993EfficientSO,
  title={Efficient screening of p53 mutations by denaturing gradient gel electrophoresis in colorectal tumors.},
  author={Richard C Hamelin and No{\"e}l Jego and Pierre Laurent-Puig and Michel Vidaud and George K. Thomas},
  journal={Oncogene},
  year={1993},
  volume={8 8},
  pages={
          2213-20
        }
}
Alterations in exons 5-8 of the p53 gene have been found in the vast majority of human tumors. Although some specific codons have been revealed as preferential mutational sites in defined tumor types, mutations are generally so scattered within this region that various screening methods for their detection have been widely used. However, the capacity of these techniques to detect exhaustively all mutations has not been evaluated. In this report, conditions for analysing exons 5-8 of the p53… CONTINUE READING

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