Efficient revascularization by VEGF administration via heparin-functionalized nanoparticle-fibrin complex.

@article{Chung2010EfficientRB,
  title={Efficient revascularization by VEGF administration via heparin-functionalized nanoparticle-fibrin complex.},
  author={Yong-Il Chung and Sang-ki Kim and Youn-Kyung Lee and Su-Jin Park and Kyoung-Oh Cho and Soon Hong Yuk and Giyoong Tae and Young Ha Kim},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2010},
  volume={143 3},
  pages={282-9}
}
We investigated the angiogenic bioactivity and therapeutic angiogenic effect of vascular endothelial growth factor (VEGF) administration by the heparin-functionalized nanoparticle-fibrin gel complex. The markedly increased bioactivity was observed by the VEGF-loaded nanoparticle-fibrin gel complex, compared to the VEGF-loaded fibrin gel, the nanoparticle-fibrin gel complex without VEGF, or fibrin gel (control) in terms of the capillary density in a mouse subcutaneous implantation model… CONTINUE READING