Efficient rejoining of radiation-induced DNA double-strand breaks in vertebrate cells deficient in genes of the RAD52 epistasis group

@article{Wang2001EfficientRO,
  title={Efficient rejoining of radiation-induced DNA double-strand breaks in vertebrate cells deficient in genes of the RAD52 epistasis group},
  author={Huichen Wang and Zhao-Chong Zeng and T Bui and Eiichiro Sonoda and Minoru Takata and Shunichi Takeda and George Iliakis},
  journal={Oncogene},
  year={2001},
  volume={20},
  pages={2212-2224}
}
Rejoining of ionizing radiation (IR) induced DNA DSBs usually follows biphasic kinetics with a fast (t50: 5–30 min) component attributed to DNA-PK-dependent non-homologous endjoining (NHEJ) and a slow (t50: 1–20 h), as of yet uncharacterized, component. To examine whether homologous recombination (HR) contributes to DNA DSB rejoining, a systematic genetic study was undertaken using the hyper-recombinogenic DT40 chicken cell line and a series of mutants defective in HR. We show that DT40 cells… CONTINUE READING

6 Figures & Tables

Connections & Topics

Mentioned Connections BETA
We propose that , in contrast to yeast , cells of vertebrates are ‘ hard - wired’ in the utilization of NHEJ as the main pathway for rejoining of IR - induced DNA DSBs and speculate that the contribution of homologous recombination repair ( HRR ) is at a stage after the initial rejoining .
We propose that , in contrast to yeast , cells of vertebrates are ‘ hard - wired’ in the utilization of NHEJ as the main pathway for rejoining of IR - induced DNA DSBs and speculate that the contribution of homologous recombination repair ( HRR ) is at a stage after the initial rejoining .
We propose that , in contrast to yeast , cells of vertebrates are ‘ hard - wired’ in the utilization of NHEJ as the main pathway for rejoining of IR - induced DNA DSBs and speculate that the contribution of homologous recombination repair ( HRR ) is at a stage after the initial rejoining .
We propose that , in contrast to yeast , cells of vertebrates are ‘ hard - wired’ in the utilization of NHEJ as the main pathway for rejoining of IR - induced DNA DSBs and speculate that the contribution of homologous recombination repair ( HRR ) is at a stage after the initial rejoining .
We propose that , in contrast to yeast , cells of vertebrates are ‘ hard - wired’ in the utilization of NHEJ as the main pathway for rejoining of IR - induced DNA DSBs and speculate that the contribution of homologous recombination repair ( HRR ) is at a stage after the initial rejoining .
We propose that , in contrast to yeast , cells of vertebrates are ‘ hard - wired’ in the utilization of NHEJ as the main pathway for rejoining of IR - induced DNA DSBs and speculate that the contribution of homologous recombination repair ( HRR ) is at a stage after the initial rejoining .
All Topics