Efficient production of transgenic mice by intracytoplasmic injection of streptolysin-O-treated spermatozoa.

Abstract

Many methods for efficient production of transgenic animals for biomedical research have been developed. Despite great improvements in transgenesis rates resulting from the use of intracytoplasmic sperm injection (ICSI), the ICSI-based sperm-mediated gene-transfer (iSMGT) technique is still not optimal in terms of sperm permeabilization efficiency and… (More)
DOI: 10.1002/mrd.22158

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