Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance

@article{Limmer2000EfficientPO,
  title={Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance},
  author={Andreas Limmer and Jutta Ohl and Christian Kurts and H O Ljunggren and Yuval Reiss and Marcus Groettrup and Frank Momburg and Bernd Arnold and Percy A Knolle},
  journal={Nature Medicine},
  year={2000},
  volume={6},
  pages={1348-1354}
}
Myeloid antigen-presenting cells (APC) are known to cross-present exogenous antigen on major histocompatibility class I molecules to CD8+ T cells and thereby induce protective immunity against infecting microorganisms. Here we report that liver sinusoidal endothelial cells (LSEC) are organ-resident, non-myeloid APC capable of cross-presenting soluble exogenous antigen to CD8+ T cells. Though LSEC employ similar molecular mechanisms for cross-presentation as dendritic cells, the outcome of cross… CONTINUE READING