Efficient polyethylenimine-mediated gene delivery proceeds via a caveolar pathway in HeLa cells.

@article{Gabrielson2009EfficientPG,
  title={Efficient polyethylenimine-mediated gene delivery proceeds via a caveolar pathway in HeLa cells.},
  author={Nathan P. Gabrielson and Daniel W Pack},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2009},
  volume={136 1},
  pages={54-61}
}
Most in vivo gene therapies will require cell-specific targeting. Although vector targeting through ligand attachment has met with success in generating gene delivery particles that are capable of specific cellular interactions, little attention has been given to the possible effects of such ligands on subsequent intracellular processing. In this study, we examine the impact of targeting two distinct endocytic routes-the caveolar and clathrin pathways-on polyethylenimine-mediated gene delivery… CONTINUE READING
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